Chemical and Biomolecular Engineering Faculty Research

Title

Nanoparticles for Drug Delivery Prepared from Amphiphilic Plga Zwitterionic Block Copolymers with Sharp Contrast in Polarity Between Two Blocks

Document Type

Article

Publication Date

Spring 2010

Abstract

In sharp contrast: Poly(carboxybetaine) (PCB)–poly(lactic-co-glycolic acid) (PLGA) block copolymers were obtained by inclusion of tBu groups onto the PCB monomers. The resulting self-assembled PLGA core/PCB shell nanoparticles have extraordinary stability and a high potential for functionalization because of the COO− groups on the PCB shell (see picture; EDC=1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS=N-hydroxysuccinimide).

Volume

122

First Page

3859

Last Page

3864