Chemistry Faculty Research

Title

Biocompatible Flavone-Based Fluorogenic Probes for Quick Wash-Free Mitochondria! Imaging in Living Cells

Document Type

Article

Publication Date

Winter 12-20-2014

Abstract

Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and apoptosis mechanism.

Publication Title

ACS Applied Materials & Interfaces

Volume

6

Issue

23

First Page

21638

Last Page

21644